Evidence-based ingredient data

Ingredient Safety Database

72 flagged ingredients from IARC, FDA, EFSA, WHO and EWG data. Search by name, alias, or category to see the concern and original source.

High concern
Medium concern
Lower concern

High Concern

(38)

Sodium Nitrite

HIGH
Preservative

IARC classifies processed meat containing nitrites as a Group 1 carcinogen (causes colorectal cancer).

Source: IARC / WHO

Sodium Nitrate

HIGH
Preservative

Converts to nitrite in the body; linked to colorectal cancer risk when consumed in processed meats.

Source: IARC / WHO

Red 3 (Erythrosine)

HIGH
Artificial Colour

FDA banned Red 3 in food and ingested drugs in January 2025 after studies showed it causes thyroid tumours in male rats.

Source: FDA

Potassium Bromate

HIGH
Flour Treatment Agent

IARC Group 2B possible carcinogen.

Source: IARC

Titanium Dioxide

HIGH
Food Colour / Coating

EU banned titanium dioxide as a food additive in 2022.

Source: EFSA / EU Commission

BHA (Butylated Hydroxyanisole)

HIGH
Preservative / Antioxidant

IARC Group 2B possible carcinogen.

Source: IARC / NTP

Butylparaben

HIGH
Preservative

Endocrine disruptor that mimics oestrogen.

Source: EWG / EU Commission

Propylparaben

HIGH
Preservative

Endocrine disruptor; affects testosterone and male reproductive function in animal studies.

Source: EWG / EFSA

DMDM Hydantoin

HIGH
Formaldehyde Releaser

Preservative that slowly releases formaldehyde (an IARC Group 1 carcinogen) as it breaks down.

Source: EWG / IARC

Quaternium-15

HIGH
Formaldehyde Releaser

One of the most common formaldehyde-releasing preservatives.

Source: EWG / ACDS

Oxybenzone (Benzophenone-3)

HIGH
UV Filter

FDA proposed in 2021 that oxybenzone cannot be classified as "generally recognised as safe" due to endocrine disruption concerns.

Source: FDA

Triclosan

HIGH
Antimicrobial

FDA banned triclosan from over-the-counter antibacterial soaps in 2016, concluding it was not proven safe.

Source: FDA

Partially Hydrogenated Oils

HIGH
Fat / Oil

FDA revoked GRAS status for partially hydrogenated oils in 2018 because artificial trans fats raise LDL cholesterol, lower HDL, and increase heart attack and stroke risk.

Source: FDA / WHO

Brominated Vegetable Oil

HIGH
Emulsifier

FDA revoked authorisation for BVO in July 2024 after studies showed it accumulates in the body and causes harm to the thyroid.

Source: FDA

Cocamide DEA

HIGH
Surfactant

IARC Group 2B possible carcinogen.

Source: IARC / California OEHHA

Red 2 (Amaranth)

HIGH
Artificial Colour

Banned in the USA since 1976 after studies indicated it may cause cancer in animals.

Source: FDA

PFOA (Perfluorooctanoic acid)

HIGH
PFAS

IARC Group 1 carcinogen (causes kidney cancer and testicular cancer in humans).

Source: IARC

PFOS (Perfluorooctane sulfonic acid)

HIGH
PFAS

IARC Group 1 carcinogen.

Source: IARC

DEHP (Di(2-ethylhexyl) phthalate)

HIGH
Plasticiser / Phthalate

IARC Group 2B possible carcinogen.

Source: IARC / EU ECHA

DBP (Dibutyl Phthalate)

HIGH
Plasticiser / Phthalate

EU reproductive toxin Category 1B.

Source: EU ECHA / EWG

BBP (Benzyl Butyl Phthalate)

HIGH
Plasticiser / Phthalate

EU reproductive toxin.

Source: EU ECHA

Glyphosate

HIGH
Pesticide

IARC Group 2A probable carcinogen.

Source: IARC

Chlorpyrifos

HIGH
Pesticide

Organophosphate neurotoxin.

Source: EPA

Atrazine

HIGH
Pesticide

One of the most common drinking water contaminants in the US.

Source: EPA / NRDC

Lead

HIGH
Heavy Metal

IARC Group 1 carcinogen (inorganic lead compounds).

Source: IARC / WHO

Arsenic

HIGH
Heavy Metal

IARC Group 1 carcinogen.

Source: IARC / WHO

Cadmium

HIGH
Heavy Metal

IARC Group 1 carcinogen — causes lung and kidney cancer.

Source: IARC / EFSA

Mercury

HIGH
Heavy Metal

Potent neurotoxin.

Source: WHO

Talc (Talcum Powder)

HIGH
Cosmetic Ingredient

IARC Group 1 carcinogen for perineal (genital) use — classified as causing ovarian cancer in 2023.

Source: IARC

1,4-Dioxane

HIGH
Contaminant

IARC Group 2B possible carcinogen.

Source: IARC / EPA

Hydroquinone

HIGH
Skin Lightener

Skin-lightening agent.

Source: EWG / EU Commission

Formaldehyde

HIGH
Preservative / Contaminant

IARC Group 1 carcinogen — causes nasopharyngeal cancer and leukaemia.

Source: IARC

Coal Tar

HIGH
Coal Tar Derivative

IARC Group 1 carcinogen for coal tar pitch.

Source: IARC / EWG

Toluene

HIGH
Solvent

Solvent used in nail polishes and hair dyes.

Source: EWG / EU Commission

DEA / TEA / MEA (Ethanolamines)

HIGH
Emulsifier / pH Adjuster

Can react with nitrites in formulations to form carcinogenic nitrosamines.

Source: EWG / EU Commission

Styrene

HIGH
Plastic Contaminant

IARC Group 2A probable carcinogen.

Source: IARC / NTP

Perchloroethylene (PERC)

HIGH
Solvent / Contaminant

IARC Group 1 carcinogen.

Source: IARC / EPA

Benzene

HIGH
Contaminant

IARC Group 1 carcinogen — causes leukaemia and other blood cancers.

Source: IARC / FDA

Medium Concern

(28)

Aspartame

MEDIUM
Artificial Sweetener

IARC classified aspartame as a Group 2B possible carcinogen in July 2023, noting limited evidence of liver cancer in humans.

Source: IARC / WHO

BHT (Butylated Hydroxytoluene)

MEDIUM
Preservative / Antioxidant

EWG rates BHT with high concern for cancer.

Source: EWG / NIH NTP

Red 40 (Allura Red)

MEDIUM
Artificial Colour

One of the "Southampton Six" food dyes.

Source: EFSA / Lancet

Yellow 5 (Tartrazine)

MEDIUM
Artificial Colour

Southampton Six dye linked to hyperactivity in children.

Source: EFSA / Lancet

Yellow 6 (Sunset Yellow)

MEDIUM
Artificial Colour

Southampton Six dye.

Source: EFSA

Blue 2 (Indigotine)

MEDIUM
Artificial Colour

Animal studies showed statistically elevated brain tumour rates in male rats.

Source: EWG / FDA

Sodium Benzoate

MEDIUM
Preservative

Reacts with Vitamin C (ascorbic acid) in drinks to form benzene, an IARC Group 1 carcinogen.

Source: FDA / EFSA

Methylparaben

MEDIUM
Preservative

Widely used preservative with oestrogenic activity.

Source: EWG

Ethylparaben

MEDIUM
Preservative

Oestrogenic activity similar to other parabens.

Source: EWG

Imidazolidinyl Urea

MEDIUM
Formaldehyde Releaser

Formaldehyde-releasing preservative.

Source: EWG

Octinoxate (Ethylhexyl Methoxycinnamate)

MEDIUM
UV Filter

FDA flagged as needing more safety data in 2021.

Source: FDA

Sodium Laureth Sulfate (SLES)

MEDIUM
Surfactant

Can be contaminated with 1,4-dioxane (an IARC Group 2B probable carcinogen) during manufacturing.

Source: EWG / FDA

Carrageenan

MEDIUM
Thickener / Stabiliser

Animal studies show degraded carrageenan causes intestinal inflammation, ulceration, and colon tumours.

Source: NIH / Cornucopia Institute

Polysorbate 80

MEDIUM
Emulsifier

A 2015 Nature study found polysorbate 80 disrupts gut microbiota, promotes low-grade inflammation, and accelerated obesity and metabolic syndrome in mice.

Source: NIH / Nature

Sulphites / Sulfites

MEDIUM
Preservative / Allergen

Mandatory allergen under EU and UK food law.

Source: FDA / FSA

Fragrance / Parfum

MEDIUM
Undisclosed Chemicals

A single "fragrance" listing can hide hundreds of undisclosed chemicals, including known allergens, endocrine disruptors, and sensitisers.

Source: EWG

Propyl Gallate

MEDIUM
Preservative / Antioxidant

Antioxidant preservative suspected of endocrine disruption.

Source: EWG / NIH

Caramel Colour (Class IV)

MEDIUM
Artificial Colour

Class IV caramel colour is produced using ammonia and sulfites, generating 4-methylimidazole (4-MEI), a California Prop 65 listed possible carcinogen.

Source: California OEHHA / IARC

Green 3 (Fast Green FCF)

MEDIUM
Artificial Colour

Animal studies found bladder and testes tumours at high doses.

Source: EWG / FDA

Ponceau 4R (Red 102)

MEDIUM
Artificial Colour

One of the Southampton Six food dyes linked to hyperactivity in children.

Source: EFSA / Lancet

Carboxymethylcellulose (CMC)

MEDIUM
Emulsifier

A 2015 Nature study found CMC disrupts gut microbiota, promotes low-grade intestinal inflammation, and increases obesity and metabolic syndrome risk in mice.

Source: NIH / Nature

Polysorbate 60

MEDIUM
Emulsifier

Same class of emulsifier as polysorbate 80.

Source: EWG / NIH

High Fructose Corn Syrup

MEDIUM
Sweetener / Additive

Linked to metabolic syndrome, obesity, type 2 diabetes, and non-alcoholic fatty liver disease.

Source: WHO / NIH

Sucralose

MEDIUM
Artificial Sweetener

WHO 2023 guidelines advise against non-sugar sweeteners.

Source: WHO / Journal of Toxicology

GenX Chemicals

MEDIUM
PFAS

Developed as a replacement for PFOA but exhibits similar toxicity and persistence.

Source: EPA

Aluminium Salts

MEDIUM
Antiperspirant Agent

Used in antiperspirants.

Source: EWG

Resorcinol

MEDIUM
Hair Dye / Keratolytic

Used in hair dyes and acne treatments.

Source: EWG / EU Commission

Cyclopentasiloxane (D5)

MEDIUM
Silicone

Silicone compound used in hair care and moisturisers.

Source: EU ECHA

Lower Concern

(6)

Data sourced from IARC, FDA, EFSA, WHO and EWG public data. For informational purposes only. This database does not constitute medical or legal advice. Learn more about ProductSafer.