Severe Combined Vitamin B12 and Folate Deficiency Presenting

Long-term proton pump inhibitors linked to B12 and folate deficiency

People who take proton pump inhibitors for more than a year may develop serious deficiencies in vitamin B12 and folate. These deficiencies can cause anemia and other health problems that mimic other conditions. If you take these acid-reflux medications long-term, talk to your doctor about monitoring your vitamin levels.